Jason Hope looks for real-world Fountain of Youth in atherosclerosis research

Over the past few decades, it has become clear that many of the diseases affecting those of advancing age are actually highly treatable. In fact, many of these diseases share a common etiology, with inflammation and related biological processes being a primary cause of many of the diseases that geriatric cohorts face.

Jason Hope is one of the state of Arizona’s most prolific entrepreneurs. Over the course of the last 20 years, he has started dozens of highly successful companies. These have included premium mobile content streaming services as well as app development companies for business applications and other areas.

Recently, it has come to light that Hope has made one of the largest contributions ever received by the SENS Foundation, one of the most prestigious private research organizations in the United States. Hope was able to donate more than a half a million dollars to the firm, ensuring that it will be able to operate a four-person full-time research team over the next year.

The funds have been earmarked for atherosclerosis research, a disease that has been implicated in the deaths of more than 1 million Americans every year. As a close follower of the medical literature, Hope has long been aware that the same basic biological processes that underlie atherosclerosis may be at the heart of many other diseases associated with the aging process.

As Hope has explained, aging itself can be viewed as a disease entity. People who live past the age of 50 are typically at vastly increased risk of almost every major disease state. This is at least partially due to increasing incidence of inflammation happening within all body systems as people age. In atherosclerosis, the inflammation is the direct product of small injuries to the vascular walls. These injuries are caused by free floating particulates, such as lipids and other fatty substances. Once the cell wall has been injured, the body initiates an inflammatory response, isolating the site of the injury and any fatty substances that may be lodged in the area.

Over time, this cycle of injury and inflammation can lead to serious occlusions of arteries and even the production of free-floating blood clots. But the same process is also present in many other disease states. These include such disease as rheumatoid arthritis, glaucoma and even renal failure. Hope believes that getting to the bottom of atherosclerosis may hold the key to unlocking the secrets of aging.

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